Haptenic determinants will react with which of the following?

Haptenic determinants are small molecules that, when combined with a larger carrier protein, can elicit an immune response. They are not capable of inducing an immune response on their own because they are too small to be recognized as antigens by the immune system. Instead, they require attachment to a carrier to create a sufficiently large structure that the immune system can recognize.

The interaction of haptenic determinants specifically with antibodies but not with T cells is key to understanding the dynamics of how these small molecules function in immunological contexts. B cells are responsible for producing antibodies; thus, they can recognize haptenic determinants when these haptens are presented by a carrier protein. This interaction allows for the generation of specific antibodies against the hapten.

T cells, however, primarily recognize processed peptide fragments presented by Major Histocompatibility Complex (MHC) molecules on the surface of antigen-presenting cells. Since haptens themselves do not generate peptide fragments suitable for MHC binding, they do not directly stimulate T cells. Therefore, haptenic determinants will react with antibodies produced by B cells but do not have a direct impact on T cell activation.

This understanding highlights the significance of the relationship between haptenic determinants and the antibody response, which