What condition is typically associated with a monoclonal spike of IgG, Bence Jones proteinuria, and bone pain?

The condition associated with a monoclonal spike of IgG, Bence Jones proteinuria, and bone pain is multiple myeloma. This disease is characterized by the proliferation of monoclonal plasma cells in the bone marrow, leading to the production of monoclonal immunoglobulins, which can be detected as a spike on serum protein electrophoresis. The presence of Bence Jones proteins, which are free light chains of immunoglobulins found in urine, is another hallmark of multiple myeloma and is indicative of the disease due to the excess of these light chains produced by neoplastic plasma cells. Additionally, patients with multiple myeloma commonly experience bone pain due to osteolytic lesions resulting from the bone marrow's infiltration by the malignant plasma cells.

Other conditions may present with similar findings but do not typically combine them in the same way as seen in multiple myeloma. For example, chronic lymphocytic leukemia often involves lymphocytosis and does not typically present with a prominent monoclonal spike of IgG or Bence Jones proteinuria. Waldenström macroglobulinemia is characterized by elevated levels of IgM rather than IgG, and while it can cause hyperviscosity syndrome, it does not