What type of antibodies are tested during the acute phase of Hepatitis B infection?

In the acute phase of Hepatitis B infection, the immune response predominantly includes the production of IgM antibodies. These antibodies are typically the first to appear in the serum following initial infection and indicate a recent exposure to the virus. The presence of IgM antibodies to Hepatitis B core antigen (anti-HBc IgM) is a key marker used to diagnose acute Hepatitis B virus (HBV) infection. They reflect the body's immediate response to the viral infection and serve as an important clinical indicator for healthcare providers.

Other antibody types, such as IgG, usually develop later in the course of infection and are more indicative of recovery or chronic infection. IgA and IgE antibodies play different roles in the immune response and are not specifically relevant to diagnosing acute Hepatitis B infections. Thus, the selection of IgM antibodies for testing during the acute phase is crucial for timely diagnosis and management of the infection.