Which antibodies would typically increase first in hepatitis A infection?

In the case of hepatitis A infection, the immune system responds by producing specific antibodies to combat the virus. The antibody class that typically rises first in response to a new infection is IgM.

IgM antibodies are produced early during the immune response and indicate a primary response to a recent infection. They are the first type of antibody to be generated by the B cells when the body encounters a pathogen like the hepatitis A virus. The presence of IgM antibodies is a key marker for acute hepatitis A infection and is often used in diagnostic testing to confirm current infection.

In contrast, the other antibody types mentioned have different roles and timing in the immune response. IgA is primarily associated with mucosal immunity and might not show a quick response to this systemic viral infection. IgE is mainly involved in allergic reactions and responses to parasitic infections, whereas IgG antibodies typically appear later as part of the immune response and are associated with long-term immunity. In the case of hepatitis A, IgG would rise after the initial IgM response as the body begins to establish a memory against the virus.

Understanding the timeline and function of these antibodies enhances the ability to diagnose and manage infections effectively.