Which immunoglobulin deficiency is commonly associated with severe respiratory infections?

The association of IgG deficiency with severe respiratory infections is based on the role of IgG in the immune response. IgG is the most abundant type of antibody found in the blood and extracellular fluid, playing a crucial role in identifying and neutralizing pathogens such as bacteria and viruses. It is particularly important for opsonization, which enhances the ability of phagocytic cells to clear infections.

Individuals with IgG deficiency often exhibit recurrent infections, especially respiratory infections, due to their impaired ability to fight off pathogens effectively. They may experience frequent bouts of pneumonia, sinusitis, and bronchitis because their immune system is less equipped to handle airborne pathogens or those that invade the respiratory tract.

While other types of immunoglobulin deficiencies can lead to various infections, the link between IgG deficiency and respiratory infections is particularly pronounced due to the critical role of IgG in providing immunity in those areas.

In contrast, IgA deficiency can lead to mucosal infections, particularly in the respiratory and gastrointestinal tracts, but it is not as directly linked to life-threatening respiratory infections as IgG deficiency. IgM deficiency may also lead to increased susceptibility to infections, specifically during the initial stages of exposure, but it is less commonly reported. IgE deficiency is